The synthesis of a particular compound from commercially available starting
materials is fundamental to nearly all aspects of organic chemistry. There are
usually many possible routes for the synthesis of even simple molecules but
which is preferred?
The aim of this short text is to give guidelines to enable you to design
strategies for the efficient synthesis of a range of molecules including simple
mono and disubstituted compound and even more complex molecules such as the
pyrrolizidine alkaloids. Our approach is based upon retro synthetic analysis and
the importance of bond polarity is emphasized throughout the discussion. In
addition we have highlighted some of the mild reagents which are now available
to effect chemo-regio-and stereo selective reactions.